Ricerca: Characterization of immune reservoirs involved in the adaptative cardiac remodeling to pressure overload
Ricerca: Identification of new factors required for telomere capping in Drosophila
Ricerca: Expression of the ligands of the activating NK cell receptors NKG2D and DNAM-1 in human cytomegalovirus infected cells: role of the DNA damage response pathway.
Bacterial infections of the gastrointestinal tract represent a serious global health concern. Childhood diarrhoea in the developing countries and among travellers is a common pathology, affecting millions of people. The major goal of this research project is to shed light on the interplay that in the typical enteropathogenic Escherichia coli (EPEC) strain E2348/69 occurs at the level of the horizontally acquired chromosomal islands LEE (locus of enterocyte effacement) and AFI (acid fitness island). This interplay, which appears to be essential for timely activation of acid resistance genes in the stomach and virulence genes in the intestine, remains poorly defined in EPEC at both genetic and molecular levels. Our analysis will be also extended to the virulence plasmid pMAR2, which carries the genes for the bundle-forming pili. Further, we will pursue a biochemical and structural characterization of the acid resistance regulator GadX and of the GadA/B decarboxylases with the aim of providing a more clear picture of the events that at the molecular level lead to the intracellular activation of glutamate-dependent AR. The role played by the AFI genes in terms of their ability to affect bacterial motility, aggregation and biofilm formation will be also investigated. Impairment in any of the above abilities is also linked to the pathogenic process. We expect that our work will also contribute to spot useful targets for therapeutics or vaccines.
Ricerca: PDZ domains in cancer
Ricerca: Comunicazioni tra un ceppo aderente-invasivo di Escherichia coli (AIEC) e il nucleo cellulare dell’ospite: ruolo dei meccanismi epigenetici ospite/batterio coinvolti nel danno al DNA cellulare e nei sistemi di riparazione.
Ricerca: Towards a therapy for mithocondrial tRNA disorders
Ricerca: Taming HIPK2 kinase activity to tackle cellular diseases and cancer
Ricerca: Immunometabolic checkpoints of Treg performance in HCV-related metabolic inflammation and cancer
Ricerca: A Drosophila model for Spinal Muscular Atrophy (SMA)
Ricerca: Interleukin 32:molecular expression, epigenetic regulation and biological activities in human HIV-1 infection
Ricerca: Study of the thyroid hormone T3 in skeletal muscle homeostasis: a possible role in muscle wasting