Il Corso Viruses and Human cancer si terrà dal 8 al 13 luglio presso l'Istituto Pasteur Italia ed è un evento organizzato nell'ambito dei corsi di formazione del Network Internazionale degli Istituti Pasteur (Direttori: Angela Santoni per l'IP Italia e Jean Pierre Vartanian per l'IP Paris). Scarica il Programma; L'application Form e il Poster.

Deadline per applicare: 15 maggio 2019

Summary of the course

Considerable worldwide efforts are being done during the last two decades to improve our
understanding of the molecular biology of viruses and the mechanisms by which they cause
disease, notably their link with carcinogenesis, which continue to be a leading cause of human
death. In parallel, our molecular understanding of cancer biology has made substantial
progress. During recent years, it became evident that inflammation is a major driving force in
tumors development since chronic virus infection and carcinogenesis are closely correlated.
As obligatory intracellular parasites, viruses encode proteins that reprogram host cellular
signaling pathways that control proliferation, differentiation, cell death, genomic integrity,
and recognition by the immune system. Development of treatment and prevention strategies
critically depends on the double understanding of the mechanism of cell tumorigenesis and
the way they are influenced by viruses.
We will discuss during this course, how viruses can act at different stages in the complex
multistep process of carcinogenesis. Early events include their involvement in mutagenic
events associated with tumor initiation such as viral integration and insertional mutagenesis as
well as viral promotion of DNA damage. Also involved in tumor progression is the
dysregulation of cellular processes by viral proteins.
This course is located at the intersection between virology, immunology and cancer. The aim
of the course is to educate graduates and post-graduates with understanding and expertise in
virology, with a particular focus on viruses and human cancers. Mechanisms by which viruses
escape from the immune system will be also discussed. This specific theoretical knowledge
will provide students with the critical judgement and skills to pursue a career in virology,
immunology and cancer. The focus of this course will be to strengthen the knowledge and
competence of students in this field.
The program has a significant theoretical teaching component to ensure that the students gain
maximal exposure to a wide range of clinically relevant viruses associated with human
cancers. The frame-work of the course (7 days) will not allow the opportunity to organize
practical work. However, to ensure interactivity, students in small groups will prepare a
bibliographical analysis under the guidance of a tutor and will present their work to the whole
class. It will be a great opportunity to allow students to discuss with experts, ask questions,
and participate in a global exchange, paving the way for future collaborations.

 

Practical information

Location Institut Pasteur Italia (Rome)

Dates of the course 08 July to 13 July 2019

Language English

 

• Dr. Jean-Pierre Vartanian

 

Department of Virology, Institut Pasteur, Paris

Tel : +33 1 44 38 94 45

Email : jean-pierre.vartanian@pasteur.fr

 

• Pr. Angela Santoni

Institut Pasteur of Rome, Scientific director

Department of Molecular Medicine, Sapienza University, Rome

Tel : +39 06 44340632

Email : angela.santoni@uniroma1.it

Chief administrative officer

• Maria Pia Lorenzoni

Istituto Pasteur Italia - Fondazione Cenci Bolognetti

Uffici Amministrativi e Laboratorio: Viale Regina Elena 291, 00161 Roma – Italia

Tel. + 39 06.49255627/8, Interno 36627/8

Fax + 39 06.49255629

data evento: 
08-07-2019
09-07-2019
10-07-2019
11-07-2019
12-07-2019
13-07-2019
contatto: 
Angela Santoni (angela.santoni@uniroma1.it) and Jean Pierre Vartanian (
area di ricerca: 
Struttura e biologia dei microorganismi
Meccanismi patogenetici delle malattie associate alle infezioni
Immunologia cellulare e molecolare